Abrogating TCR Signaling Inhibits Th2 Cytokine Synthesis by An Altered Peptide Ligand Specifically
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منابع مشابه
TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization.
We examined the role of the peptide/MHC ligand in CD4+ T cell differentiation into Th1 or Th2 cells using a TCR alphabeta transgenic mouse specific for hemoglobin (Hb)(64-76)/I-Ek. We identified two altered peptide ligands of Hb(64-76) that retain strong agonist activity but, at a given dose, induce cytokine patterns distinct from the Hb(64-76) peptide. The ability of these peptides to produce ...
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